Adult 250 mg 6 hrly, may be increased up to ≥4 g/day.
Childn 30-50 mg/kg/day in divided doses. Severe infections: Dosage may be doubled.
Pharyngitis & tonsillitis Usual dose 20-50 mg/kg/day in divided doses.
≥36 kg 1,000 mg,
25-36 kg 750 mg,
18-25 kg 500 mg,
11-18 kg 375 mg,
<10 kg 250 mg. Prophylaxis of streptococcal infections in persons w/ history of rheumatic heart disease 250 mg bid.
Prophylaxis against bacterial endocarditis in penicillin allergic patient w/ congenital heart disease/rheumatic/other acquired valvular heart disease when undergoing dental procedure/ surgery of the upper resp tract Adult 1 g orally 1 hr pre-op, 500 mg orally 6 hr post-op.
Childn 20 mg/kg orally 1 hr pre-op, 10 mg/kg orally 6 hr post-op.
Primary syphilis 20 g in divided doses for 10 days.
Dysenteric amoebiasis Adult 250 mg qid for 10-14 days.
Childn 30-50 mg/kg/day in divided doses for 10-14 days.
Pertussis 40-50 mg/kg/day in divided doses for 5-14 days.
Legionnaire's disease 1-4 g daily in divided doses.
Conjunctivitis in newborn Oral susp 50 mg/kg/day in 4 divided doses for 2 wk.
Pneumonia of infant Oral susp 50 mg/kg/day in 4 divided doses for 3 wk.
Urogenital infections during pregnancy 500 mg qid for 7 days. For women who cannot tolerate this regimen, reduce dose to 250 mg qid for 14 days.
Uncomplicated urethral, endocervical/rectal infections 500 mg qid for 7 days.
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